Colorectal cancer-infiltrating NK cell landscape analysis unravels tissue-resident PD-1+ NK cells in microsatellite instability tumors
These results suggest, together with an increased PD-L1 expression on MSI tumor cells, that the efficacy of immunotherapies in MSI CRC based on PD-1/PD-L1 blockade could also rely on a superior anti-tumor potential of PD-1<sup>+</sup> NK cells. Conversely, MSS CRC, in which tumor-associated PD-1<sup>+</sup> NK cells are scarce, could benefit more from immunotherapies blocking NKG2A and/or KIRs. Thus, novel approaches based on NK cell features related to CRC type, fully exploiting circulating and resident NK cell anti-tumor activity, could be key to next-generation therapies.
Authors
- Mariella Della Chiesa
- Fulvia Ortolani (ORCID: https://orcid.org/0000-0001-5268-7201)
- Silvia Pesce (ORCID: https://orcid.org/0000-0002-9798-4944)
- Valentina Obino
- Simona Carlomagno (ORCID: https://orcid.org/0000-0001-8522-1176)
- Simona Sivori (ORCID: https://orcid.org/0000-0003-1279-1172)
- Matteo Bozzo (ORCID: https://orcid.org/0000-0002-7452-3758)
- Simona Candiani (ORCID: https://orcid.org/0000-0002-4453-5475)
- Mariangela Rutigliani (ORCID: https://orcid.org/0000-0002-5773-0309)
- Marco Greppi (ORCID: https://orcid.org/0000-0002-7296-009X)
- Matteo Clavarezza
- Tania Buttiron Webber (ORCID: https://orcid.org/0000-0002-3605-2828)
- Letizia Muccio
- Andrea Barberis (ORCID: https://orcid.org/0000-0003-0472-0120)
- Laura Paleari (ORCID: https://orcid.org/0000-0002-6176-2979)
- Emanuela Marcenaro (ORCID: https://orcid.org/0000-0003-4103-7566)
- E. Ciferri
- Elisa Ferretti (ORCID: https://orcid.org/0000-0001-6813-7247)
- Nicoletta Provinciali (ORCID: https://orcid.org/0000-0002-7803-3852)
- Andrea DeCensi (ORCID: https://orcid.org/0000-0003-2635-4491)
- Chiara Setti (ORCID: https://orcid.org/0009-0009-5489-7048)
- Chiara Giordano (ORCID: https://orcid.org/0009-0004-4770-1418)
- Marco Filauro
- Agnese Solari
Institutions
- University of Udine (IT)
- Queen Mary University of London (GB)
- Ente Ospedaliero Ospedali Galliera (IT)
- Gibraltar Health Authority (GI)
- Ospedale Policlinico San Martino (IT)
- University of Genoa (IT)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-06-18
- DOI
- https://doi.org/10.3389/fimmu.2025.1578444
- Citations
- 3
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 2.39