Inhibition of class IIa HDACs reduces mutant HTT aggregation by affecting RNA stability
Our data suggest a so far unknown mode of action of HDAC class IIa inhibitors by affecting <i>HTT</i> transcript levels.
Authors
- Thomas Kurz (ORCID: https://orcid.org/0000-0002-9474-4224)
- J. Schaefer (ORCID: https://orcid.org/0000-0002-9246-267X)
- Sybille Krauß (ORCID: https://orcid.org/0000-0002-5653-9289)
- Joachim Urban
- J. Bruns (ORCID: https://orcid.org/0000-0001-8802-1022)
- Annika Reisbitzer
- Andrea Geraci (ORCID: https://orcid.org/0000-0002-0174-228X)
- Maximilian Burghaus
- Cecilia Hollitzer
Institutions
- Johannes Gutenberg University Mainz (DE)
- University of Siegen (DE)
- Heinrich Heine University Düsseldorf (DE)
Publication Details
- Journal
- Frontiers in Molecular Neuroscience
- Published
- 2025-06-18
- DOI
- https://doi.org/10.3389/fnmol.2025.1579194
- Citations
- 1
- Primary Topic
- Histone Deacetylase Inhibitors Research
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Deutsche Forschungsgemeinschaft