Investigating the underlying mechanisms of the ethanol extract of saussureae involucratae herba in anti-rheumatoid arthritis effect based on sphingolipidomics
We, for the first time, found that SIE has anti-RA effects in CIA mice and that regulation of sphingolipid metabolism is involved in its anti-RA action. These findings provide pharmacological evidence for the use of SIH in managing RA and support the theory that targeting sphingolipid metabolism is a strategy for treating RA.
Authors
- Caisheng Wu (ORCID: https://orcid.org/0009-0001-3796-1791)
- Ying‐Jie Chen (ORCID: https://orcid.org/0000-0002-4604-3896)
- Peter Chi (ORCID: https://orcid.org/0000-0001-9229-8729)
- Mingyuan Liu (ORCID: https://orcid.org/0000-0002-1952-1012)
- Hairong Zhang (ORCID: https://orcid.org/0000-0002-4791-2838)
- Jianhua Xie
- Yiming Ayixianmuguli
Institutions
- Shihezi University (CN)
- Jiamusi University (CN)
- Xiamen University (CN)
- First Affiliated Hospital of Xiamen University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-06-18
- DOI
- https://doi.org/10.3389/fphar.2025.1549437
- Primary Topic
- Sphingolipid Metabolism and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Department of Education, Heilongjiang Province
- Jiamusi University