Integrative analysis of T cell-associated markers in Ewing sarcoma reveals prognostic signatures and immune dynamics
Together, our study identified <i>CLEC11A</i>, <i>BDP1</i>, and <i>ID3</i> as key T cell associated prognostic markers and developed a validated model to predict survival outcomes in ES. Insights into T cell markers and tumor-immune dynamics offer promising advances in prognostic assessment and immunotherapy for ES. Furthermore, the role of ID3 in immune evasion and tumor proliferation underscores its potential as a therapeutic target, providing new avenues for immune checkpoint regulation and personalized treatment strategies.
Authors
- Saadullah Khattak (ORCID: https://orcid.org/0000-0001-6798-2991)
- Umair Ali Khan Saddozai
- Fei Yan (ORCID: https://orcid.org/0000-0002-6429-7443)
- Haibo Sun (ORCID: https://orcid.org/0000-0002-1870-9064)
- Ping Yang (ORCID: https://orcid.org/0000-0002-6977-8449)
- Muhammad Usman Akbar (ORCID: https://orcid.org/0000-0002-8878-0675)
- Muhammad Babar Khawar (ORCID: https://orcid.org/0000-0002-1812-0591)
- Chenxu Liu (ORCID: https://orcid.org/0000-0002-9057-3755)
- Zhendong Lü
Institutions
- Henan University (CN)
- Capital Medical University (CN)
- Wenzhou Medical University (CN)
- Beijing Chest Hospital (CN)
- Shanghai Eighth People Hospital (CN)
- Yangzhou University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-06-18
- DOI
- https://doi.org/10.3389/fimmu.2025.1586544
- Citations
- 3
- Primary Topic
- Sarcoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.56