Expansion of CD103+CD69+CD8+ cytotoxic liver tissue resident memory T cells and inflammatory monocytes in advanced biliary atresia
Cytotoxic CD8<sup>+</sup> Trm cells and intrahepatic monocytes might contribute to tissue destruction in BA. Therapies targeting Trm cells or the TNF-α signaling pathway could be explored to delay progression to cirrhosis in BA.
Authors
- Ania C. Muntau (ORCID: https://orcid.org/0000-0002-2900-8378)
- Katharina Möller (ORCID: https://orcid.org/0000-0002-9739-4274)
- Søren W. Gersting (ORCID: https://orcid.org/0000-0001-7482-4748)
- Jun Oh (ORCID: https://orcid.org/0000-0003-1846-675X)
- Kevin Paul (ORCID: https://orcid.org/0000-0002-0998-4881)
- Gábor A. Dunay (ORCID: https://orcid.org/0000-0003-0371-1505)
- Uta Herden (ORCID: https://orcid.org/0000-0003-2921-7943)
- Freya Sibbertsen (ORCID: https://orcid.org/0000-0001-8907-1582)
- Sebastian Schulz‐Jürgensen (ORCID: https://orcid.org/0009-0008-3685-0783)
- Sören Weidemann (ORCID: https://orcid.org/0000-0001-7037-3265)
- Regine J. Dress (ORCID: https://orcid.org/0000-0001-8785-5471)
- Lutz Fischer (ORCID: https://orcid.org/0000-0003-0010-3563)
- Eva Tolosa
Institutions
- Universität Hamburg (DE)
- German Climate Computing Centre (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- Universitätsklinikum Brandenburg an der Havel (DE)
- Brandenburg University of Technology Cottbus-Senftenberg (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-06-18
- DOI
- https://doi.org/10.3389/fimmu.2025.1567645
- Primary Topic
- Pediatric Hepatobiliary Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Leibniz-Gemeinschaft
- Universitätsklinikum Hamburg-Eppendorf