The GLP-1 receptor agonist liraglutide inhibits necroptosis and neuroinflammation in a mouse model of Parkinson’s disease with diabetes co-morbidity
In the diabetic PD model, liraglutide is neuroprotective by reducing necroptosis and neuroinflammation through the TNF-α signaling pathway.
Authors
- Xia Lian (ORCID: https://orcid.org/0009-0001-0088-3099)
- Bo Bai (ORCID: https://orcid.org/0000-0002-3958-9874)
- Christian Hölscher (ORCID: https://orcid.org/0000-0002-8159-3260)
- Xiaomin Zhang (ORCID: https://orcid.org/0000-0002-5660-5303)
- Yongqing Wang (ORCID: https://orcid.org/0000-0001-8340-6003)
- Pengyang Du
- Guofang Xue (ORCID: https://orcid.org/0000-0001-9235-5236)
- Peng Feng
Institutions
- Shanxi Medical University (CN)
- Henan Academy of Sciences (CN)
- Second Hospital of Shanxi Medical University (CN)
Publication Details
- Journal
- Frontiers in Neuroscience
- Published
- 2025-06-18
- DOI
- https://doi.org/10.3389/fnins.2025.1596506
- Citations
- 6
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 8.34
Funders
- Shanxi Provincial Education Department