Identification and validation of a KRAS-macrophage-associated gene signature as prognostic biomarkers and potential therapeutic targets in melanoma
This study highlights the importance of KRAS signaling and macrophage infiltration in melanoma prognosis. The KMPAG gene signature presents a novel prognostic tool, offering insights into personalized treatment strategies and predictive biomarkers for immunotherapy in SKCM. Further exploration of CLEC4A's role in melanoma progression may provide new therapeutic avenues for targeted intervention.
Authors
- Jiaqi Yu (ORCID: https://orcid.org/0000-0002-0618-0116)
- Hekun Liu (ORCID: https://orcid.org/0000-0002-7986-6426)
- Beichen Cai (ORCID: https://orcid.org/0000-0002-6648-7873)
- Xuejun Ni (ORCID: https://orcid.org/0000-0002-0504-5430)
- Xiuying Shan (ORCID: https://orcid.org/0000-0002-3718-5075)
- Ruonan Ke (ORCID: https://orcid.org/0009-0001-5039-2685)
- Qian Lin (ORCID: https://orcid.org/0000-0003-4287-1018)
- Lu Chen (ORCID: https://orcid.org/0000-0002-8097-2699)
- Biao Wang (ORCID: https://orcid.org/0000-0002-0745-2355)
Institutions
- Fujian Medical University (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-06-18
- DOI
- https://doi.org/10.3389/fimmu.2025.1566432
- Primary Topic
- Melanoma and MAPK Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Fujian Province
- Fujian Provincial Health Technology Project