TIM4+macrophages suppress the proinflammatory response to maintain the chronic alveolar echinococcosis infection
Tim-4 attenuated the predominant proinflammatory response, thereby facilitating immune evasion by <i>E. multilocularis</i>. Notably, inhibition of Tim-4 in macrophages not only restored the inflammatory balance but also significantly reversed hepatic fibrotic progression.
Authors
- Xuan Zhou (ORCID: https://orcid.org/0000-0003-2522-1283)
- Maidinaimu Aibibula
- Jinping Zhou (ORCID: https://orcid.org/0000-0001-5340-0575)
- Xiumin Ma (ORCID: https://orcid.org/0000-0001-8011-7513)
- Yuyu Ma (ORCID: https://orcid.org/0000-0002-7854-2868)
- Xue Zhang (ORCID: https://orcid.org/0000-0002-9673-8987)
- Liang Wang (ORCID: https://orcid.org/0000-0001-5339-7484)
- Yumei Liu (ORCID: https://orcid.org/0009-0004-5986-4943)
- Hui Zhao (ORCID: https://orcid.org/0000-0003-1343-6316)
- Fengming Tian
Institutions
- Xinjiang Medical University (CN)
- Fifth Affiliated Hospital of Xinjiang Medical University (CN)
- First Affiliated Hospital of Xinjiang Medical University (CN)
- Tumor Hospital of Xinjiang Medical University (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-06-18
- DOI
- https://doi.org/10.3389/fcimb.2025.1600686
- Citations
- 6
- Primary Topic
- Parasitic infections in humans and animals
- Type
- article
- Field-Weighted Citation Impact
- 8.83
Funders
- Xinjiang Medical University