A genome-wide shRNA screen uncovers a novel potential ligand for NK cell activating receptors
Our study identifies PLAC1 as a novel potential ligand for NKARs, suggesting it could be a valuable target for pharmacological strategies aimed at enhancing NK cell recognition. This finding holds promise for improving the efficacy of NK cell-based immunotherapies and advancing their clinical application.
Authors
- Doriana Fruci (ORCID: https://orcid.org/0000-0003-3388-7296)
- Valeria Lucarini (ORCID: https://orcid.org/0000-0002-3553-8818)
- Valentina Folgiero (ORCID: https://orcid.org/0000-0002-9838-1520)
- Franco Locatelli (ORCID: https://orcid.org/0000-0002-7976-3654)
- Loredana Cifaldi (ORCID: https://orcid.org/0000-0001-5014-430X)
- Valerio D’Alicandro
- Ombretta Melaiu (ORCID: https://orcid.org/0000-0001-7118-5186)
- Paolo Romania (ORCID: https://orcid.org/0000-0001-6855-1464)
- Roberto Bei (ORCID: https://orcid.org/0000-0001-9541-8896)
- Matteo Caforio
- Paula Gragera (ORCID: https://orcid.org/0009-0007-5088-1757)
Institutions
- Università Cattolica del Sacro Cuore (IT)
- University of Rome Tor Vergata (IT)
- Bambino Gesù Children's Hospital (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-06-18
- DOI
- https://doi.org/10.3389/fimmu.2025.1537876
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- Ministero della Salute
- Fondazione Umberto Veronesi
- Associazione Italiana per la Ricerca sul Cancro
- Horizon 2020 Framework Programme
- H2020 Marie Skłodowska-Curie Actions