Detecting Mitochondrial Oxygen Tension as a Measure of Local Tissue Oxygenation in Patients With Peripheral Arterial Disease Before and After Endovascular Therapy
5-ALA is tolerable and safe in patients with PAD. MitPO<sub>2</sub> measurements at the tibia and lower lateral leg are feasible and capable of detecting changes in perfusion following endovascular therapy. Further research is needed with larger cohorts and longer follow-up to investigate the relationship between mitoPO<sub>2</sub>, oxygen supply, and tissue regeneration.Clinical ImpactThis study demonstrated the feasibility and safety of mitochondrial oxygen tension (mitoPO<sub>2</sub>) measurement using 5-aminolevulinic acid (5-ALA) for assessing local skin perfusion in patients with peripheral arterial disease (PAD) undergoing endovascular therapy. Changes in mitoPO<sub>2</sub> post-intervention suggest sensitivity to real-time microvascular and physiological alterations. This technique could potenitally improve overall patient outcomes and wound healing by enhancing patient stratification, treatment planning, perioperative monitoring, and postoperative follow-up.
Authors
- Reinoud P.H. Bokkers (ORCID: https://orcid.org/0000-0001-6130-7311)
- Riemer H. J. A. Slart (ORCID: https://orcid.org/0000-0002-5565-1164)
- Jean‐Paul P.M. de Vries (ORCID: https://orcid.org/0000-0002-2669-320X)
- Richte C. L. Schuurmann (ORCID: https://orcid.org/0000-0001-7253-3939)
- Abdallah H. A. Zaid Al-Kaylani (ORCID: https://orcid.org/0000-0003-1332-3346)
Institutions
- University Medical Center Groningen (NL)
- University of Groningen (NL)
Publication Details
- Journal
- Journal of Endovascular Therapy
- Published
- 2025-06-17
- DOI
- https://doi.org/10.1177/15266028251344791
- Citations
- 1
- Primary Topic
- Peripheral Artery Disease Management
- Type
- article
- Field-Weighted Citation Impact
- 2.01