Standardized aqueous extract of Abutilon theophrasti Medic. ameliorates oxidative stress and inflammatory responses against hydrochloric acid/ethanol-induced gastric ulcer in rats
ATAE ameliorates oxidative stress and inflammatory responses against HCl/EtOH-induced GU in rats, which are probably associated with inhibiting the ROS/Akt/NF-κB signaling pathway. The novel findings of this study, for the first time, provide scientific justifications for the use of AT in treating peptic ulcer. Future studies are warranted to elucidate the clinical potential and a more comprehensive understanding of the underlying mechanisms of AT in treating GU.
Authors
- Hui Guo (ORCID: https://orcid.org/0000-0003-0282-6933)
- Liping Dai (ORCID: https://orcid.org/0009-0003-0240-8763)
- Meng Zhu
- Erping Xu (ORCID: https://orcid.org/0000-0001-7384-9839)
- Mengmeng Wang (ORCID: https://orcid.org/0000-0001-8699-4496)
- Zihan Xu (ORCID: https://orcid.org/0000-0001-5499-4803)
- Lili Zhu (ORCID: https://orcid.org/0000-0003-1957-973X)
- Man Gong
- Weijin Zhang (ORCID: https://orcid.org/0000-0002-1477-7465)
- Mengyun Liu (ORCID: https://orcid.org/0000-0002-7796-1884)
Institutions
- Henan University of Traditional Chinese Medicine (CN)
- First Affiliated Hospital of Henan University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-06-18
- DOI
- https://doi.org/10.3389/fphar.2025.1599810
- Citations
- 2
- Primary Topic
- Helicobacter pylori-related gastroenterology studies
- Type
- article
- Field-Weighted Citation Impact
- 4.01
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China