Mesoporous silica nanoparticles loaded Au nanodots: a self-amplifying immunotherapeutic depot for photothermal immunotherapy

This study underscores that the strategic design of MSN@Au as a PTT agent successfully induces ICD while modulating the immunosuppressive TME, significantly amplifying therapeutic efficacy. The integration of efficient photothermal ablation with immune activation opens new avenues for developing next-generation nanoplatforms that synergize PTT with immune modulation, offering a promising strategy for treating solid tumors.