Patient-specific modelling of pulmonary arterial hypertension: wall shear stress correlates with disease severity
This study highlights TAWSS as a potential computational biomarker for PAH. The clinical use of TAWSS to diagnose and stratify PAH patients has the potential to greatly improve patient outcomes. Further work is ongoing to validate these findings in larger cohorts.
Authors
- Deepa Gopalan (ORCID: https://orcid.org/0000-0001-8079-205X)
- Ben K. Statton (ORCID: https://orcid.org/0000-0001-5118-7977)
- M. R. Wilkins
- Xiao Yun Xu (ORCID: https://orcid.org/0000-0002-8267-621X)
- Chlӧe H. Armour (ORCID: https://orcid.org/0000-0002-6459-1271)
- Declan P. O’Regan (ORCID: https://orcid.org/0000-0002-0691-0270)
- Allan Lawrie (ORCID: https://orcid.org/0000-0003-4192-9505)
- Leslie Howard
Institutions
- Imperial College Healthcare NHS Trust (GB)
- General Medical Council (GB)
- Imperial College London (GB)
- Medical Research Council (GB)
Publication Details
- Journal
- Frontiers in Bioengineering and Biotechnology
- Published
- 2025-06-18
- DOI
- https://doi.org/10.3389/fbioe.2025.1585345
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute for Health and Care Research
- British Heart Foundation
- Imperial College London
- Medical Research Council