What drives hyperammonemic encephalopathy in AED users: monotherapy risks or polypharmacy perils?
This research underscores the possible danger of HE related to AEDs, with a particular focus on the risks tied to VPA and PER when used alone, as well as VPA in conjunction with TPM, OLZ, or QTP. It emphasizes the need to monitor ammonia levels in patients on AEDs, particularly those on polypharmacy.
Authors
- Ye Guo (ORCID: https://orcid.org/0000-0002-1813-9815)
- Qing Shan (ORCID: https://orcid.org/0009-0002-7473-2493)
- Qiang Fu (ORCID: https://orcid.org/0000-0002-4523-608X)
- Jin‐Min Guo (ORCID: https://orcid.org/0000-0001-5737-7384)
- Xia Liu (ORCID: https://orcid.org/0000-0002-0180-2166)
- Lei Wang (ORCID: https://orcid.org/0000-0002-8829-0246)
- Bing Li (ORCID: https://orcid.org/0000-0002-5055-8921)
- Yan Chen (ORCID: https://orcid.org/0000-0002-1397-6358)
Institutions
- University of Jinan (CN)
- Second Hospital of Shandong University (CN)
- Jinan Infectious Disease Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-06-18
- DOI
- https://doi.org/10.3389/fphar.2025.1477127
- Citations
- 1
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- Taishan Scholar Foundation of Shandong Province