SIRT2-dependent CPT1A deacetylation in macrophages inhibits periodontitis
Overall, these findings demonstrate that <i>SIRT2</i> binds to and deacetylates <i>CPT1A</i>, thereby inhibiting osteoclast differentiation and concurrently alleviating inflammation in periodontal tissues during experimental periodontitis progression.
Authors
- Hongjiao Li
- Zhengyu Guan
- Xiu Yao
- Xiaomeng Liu (ORCID: https://orcid.org/0000-0002-3288-212X)
- Lin Zhou (ORCID: https://orcid.org/0000-0003-0265-9776)
- Yixuan Jiang
- Zhizhong Jiang (ORCID: https://orcid.org/0000-0002-5855-110X)
- Boyuan Sun
Institutions
- XinHua Hospital (CN)
- Shanghai Stomatological Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-06-18
- DOI
- https://doi.org/10.3389/fphar.2025.1574141
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China