Oral Angiotensin-(1-7) formulation after established elastase-induced emphysema suppresses inflammation and restores lung architecture
These findings suggest that Ang-(1-7), when administered after disease establishment, demonstrates potential to reverse structural lung damage and suppress chronic inflammation in experimental models, indicating a promising direction for future translational and clinical research in COPD.
Authors
- Maria da Glória Rodrigues‐Machado (ORCID: https://orcid.org/0000-0002-9950-1707)
- Alicia Villacampa (ORCID: https://orcid.org/0000-0002-7398-8545)
- Giselle Santos Magalhães (ORCID: https://orcid.org/0000-0002-2589-0332)
- Concepción Peiró (ORCID: https://orcid.org/0000-0002-9690-7816)
- Maria José Campagnole‐Santos (ORCID: https://orcid.org/0000-0001-9483-4206)
- Robson A.S. Santos (ORCID: https://orcid.org/0000-0001-8738-5852)
- Carlos F. Sánchez-Ferrer
Institutions
- National Institute of Science and Technology (ID)
- Universidad Autónoma de Madrid (ES)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-06-18
- DOI
- https://doi.org/10.3389/fphar.2025.1540475
- Citations
- 1
- Primary Topic
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- European Commission
- Fundação de Amparo à Pesquisa do Estado de Minas Gerais
- Center for Fundamentals of Subsurface Flow
- Agencia Estatal de Investigación