EVALUATION OF BIOCHEMICAL AND HEMATOLOGICAL ALTERATIONS IN PATIENTS WITH CHOLELITHIASIS: A HOSPITAL-BASED CROSS-SECTIONAL STUDY

Background:Cholelithiasis, or gallstone disease, is a common gastrointestinal condition marked by the formation of gallstones within the gallbladder, often leading to biliary obstruction, hepatic dysfunction, and inflammation. It is particularly prevalent in northern India, including Uttar Pradesh. This study was conducted to assess the biochemical and hematological changes in cholelithiasis patients. Methods:A hospital-based cross-sectional study was conducted at Teerthanker Mahaveer Hospital and Research Centre, Moradabad, Uttar Pradesh, over a duration of 6 months. A total of 240 participants were enrolled, including 118 confirmed cholelithiasis patients and 122 age- and sex-matched healthy controls. Blood samples were analyzed for total, direct, and indirect bilirubin; liver enzymes (AST, ALT, ALP); pancreatic enzymes (amylase, lipase); and inflammatory markers (CRP, TLC). Data analysis was done using SPSS software and statistical comparisons were performed using the Mann-Whitney U test. Ethical approval was obtained from the Institutional Ethical Committee, College of Paramedical Sciences (Ref. No.: PM/ETHICAL/COPS/2024/018)