Nanosecond pulsed electric field applications rejuvenate aging endothelial cells by rescuing mitochondrial-to-nuclear retrograde communication
These findings suggest that nsPEF treatments rescue ECs from aging by restoring MNRC, highlighting its potential as a therapeutic strategy for age-related vascular diseases.
Authors
- Jie Xiao (ORCID: https://orcid.org/0000-0002-4718-1174)
- Neelu Begum (ORCID: https://orcid.org/0000-0003-4408-8940)
- Meifang Yin (ORCID: https://orcid.org/0000-0002-5436-0701)
- Xiaofang Liu
- Ilaria Dal Prà (ORCID: https://orcid.org/0000-0001-5523-4910)
- Guangtao Huang (ORCID: https://orcid.org/0000-0003-0285-2381)
- Ubaldo Armato (ORCID: https://orcid.org/0000-0002-7804-6143)
- Anna Chiarini (ORCID: https://orcid.org/0000-0002-6974-7685)
- Shumaila Ijaz (ORCID: https://orcid.org/0009-0003-9614-9802)
- Huanyu Xie (ORCID: https://orcid.org/0000-0003-1470-1951)
- Hongwei Liu (ORCID: https://orcid.org/0000-0001-6471-131X)
- Lingyun Wang (ORCID: https://orcid.org/0000-0002-6367-9247)
- Jianqiang Yuan (ORCID: https://orcid.org/0000-0002-3324-8323)
- Jun Wu (ORCID: https://orcid.org/0000-0002-4997-1970)
Institutions
- University of Verona (IT)
- China Academy of Engineering Physics (CN)
- Shenzhen Second People's Hospital (CN)
Publication Details
- Journal
- Regenerative Therapy
- Published
- 2025-06-18
- DOI
- https://doi.org/10.1016/j.reth.2025.06.004
- Citations
- 1
- Primary Topic
- Microbial Inactivation Methods
- Type
- article
- Field-Weighted Citation Impact
- 1.23
Funders
- National Natural Science Foundation of China