Evaluation of amoxicillin and benzylpenicillin therapy in early-onset neonatal sepsis: a pharmacometric external validation and simulation study
(Pre)term neonates with EOS can be adequately treated with amoxicillin dosed as per the DPF regimen. By contrast, further optimization is warranted for benzylpenicillin, for which GA-based intermittent dosing or continuous infusion pose potential alternatives.
Authors
- Sophie Jansen (ORCID: https://orcid.org/0000-0002-2075-7487)
- Dimitra Eleftheriou (ORCID: https://orcid.org/0000-0003-4377-6426)
- Vincent Bekker (ORCID: https://orcid.org/0000-0002-6543-5537)
- Dirk Jan A. R. Moes (ORCID: https://orcid.org/0000-0003-3219-253X)
- Swantje Völler (ORCID: https://orcid.org/0000-0003-0587-2775)
- Tom C. Zwart (ORCID: https://orcid.org/0000-0003-3692-0901)
- Martha T. van der Beek (ORCID: https://orcid.org/0000-0003-2359-7949)
Institutions
- Leiden University (NL)
- Leiden University Medical Center (NL)
- Centre for Human Drug Research (NL)
- Haga Hospital (NL)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1093/jac/dkaf191
- Citations
- 1
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Janivo Stichting