The impact of age, sex, and comorbidities on COVID-19 mortality of hospitalized patients during the SARS-CoV-2 pandemic: data from the multicentric prospective cohort study of the Lean European Open Survey on SARS-CoV-2 (LEOSS)
Overall mortality decreased during the pandemic, even among severely immunosuppressed patients. Age, sex, and the number of comorbidities were key mortality risk factors, although their impact lessened as the pandemic progressed.
Authors
- Florian Voit (ORCID: https://orcid.org/0000-0002-6957-6628)
- Johanna Erber (ORCID: https://orcid.org/0000-0001-6614-6051)
- Susana M. Nunes de Miranda (ORCID: https://orcid.org/0000-0003-2072-6979)
- Margarete Scherer (ORCID: https://orcid.org/0000-0002-6938-6373)
- Maria Madeleine Rüthrich
- Julia Lanznaster (ORCID: https://orcid.org/0000-0002-6592-156X)
- Laura Wagner (ORCID: https://orcid.org/0000-0002-5184-8154)
- Kerstin Hellwig (ORCID: https://orcid.org/0000-0003-4467-9011)
- Christoph D. Spinner (ORCID: https://orcid.org/0000-0002-3875-5367)
- Timm Henning Westhoff (ORCID: https://orcid.org/0000-0001-5797-834X)
- Björn‐Erik Ole Jensen (ORCID: https://orcid.org/0000-0003-1626-4855)
- Maria J. G. T. Vehreschild (ORCID: https://orcid.org/0000-0003-0446-3224)
- Jochen Schneider (ORCID: https://orcid.org/0000-0002-0300-0159)
- Julian Triebelhorn
Institutions
- Goethe University Frankfurt (DE)
- University of Cologne (DE)
- Frankfurt Institute for Advanced Studies (DE)
- Universitätsklinik Marien Hospital Herne (DE)
- Düsseldorf University Hospital (DE)
- University Hospital Frankfurt (DE)
- Jena University Hospital (DE)
- St. Josef-Hospital (DE)
- Klinikum Passau (DE)
- University Hospital Cologne (DE)
- Heinrich Heine University Düsseldorf (DE)
- Technical University of Munich (DE)
- Charité - Universitätsmedizin Berlin (DE)
- Ruhr University Bochum (DE)
Publication Details
- Journal
- Infection
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1007/s15010-025-02583-z
- Primary Topic
- COVID-19 Clinical Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Technische Universität München