Metabolic adaptation to acute metabolic stress via PFKFB3 upregulation in rodent beta cells
PFKFB3 upregulation under acute metabolic stress may be an adaptive response that helps maintain beta cell function. Suppression of PFKFB3 activity compromises insulin secretion and glucose tolerance, highlighting the importance of this pathway in metabolic adaptation to transient stress.
Authors
- Koki Chiba (ORCID: https://orcid.org/0000-0003-3580-2321)
- Rimi Izumihara (ORCID: https://orcid.org/0009-0000-5525-7290)
- Akinobu Nakamura (ORCID: https://orcid.org/0000-0002-8192-0006)
- Hiroshi Nomoto (ORCID: https://orcid.org/0000-0003-0713-221X)
- Hiraku Kameda (ORCID: https://orcid.org/0000-0003-1870-6688)
- Tatsuya Atsumi (ORCID: https://orcid.org/0000-0001-5657-962X)
- Xinxin Zhang (ORCID: https://orcid.org/0000-0002-2918-9447)
Institutions
- Asahikawa Medical University (JP)
- Hokkaido University (JP)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-06-17
- DOI
- https://doi.org/10.3389/fendo.2025.1552700
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Hokkaido University