A Spindle Cell Tumor in Disguise: Histoid Nodules Arising From Peripheral Nerves

A 25-year-old male presented with multiple, painless subcutaneous nodules, each measuring 5-6 mm, attached to thickened superficial cutaneous nerves. He also had nodular infiltration of the left earlobe. Histopathology revealed spindle-shaped histiocytes in a storiform pattern, with numerous acid-fast bacilli in Fite-Faraco staining. Skin slit smear from the nodule revealed a bacteriological index of +6. Ultrasonography of the nodule revealed a well-defined, avascular, heterogenous hypoechoic lesion over a focally thickened nerve with loss of fibrillary pattern, confirming a rare form of neural histoid leprosy.

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Publication Details

Journal
Cureus
Published
2025-06-16
DOI
https://doi.org/10.7759/cureus.86173
Primary Topic
Sarcoma Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
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article

A Spindle Cell Tumor in Disguise: Histoid Nodules Arising From Peripheral Nerves

Josh Mathews, Pratik Minj, Ankur Patel, A. Narula
Cureus
Sarcoma Diagnosis and Treatment
article

A Spindle Cell Tumor in Disguise: Histoid Nodules Arising From Peripheral Nerves

Josh Mathews, Pratik Minj, Ankur Patel, A. Narula
article en

Abstract

A 25-year-old male presented with multiple, painless subcutaneous nodules, each measuring 5-6 mm, attached to thickened superficial cutaneous nerves. He also had nodular infiltration of the left earlobe. Histopathology revealed spindle-shaped histiocytes in a storiform pattern, with numerous acid-fast bacilli in Fite-Faraco staining. Skin slit smear from the nodule revealed a bacteriological index of +6. Ultrasonography of the nodule revealed a well-defined, avascular, heterogenous hypoechoic lesion over a focally thickened nerve with loss of fibrillary pattern, confirming a rare form of neural histoid leprosy.

CureusVol. 17(6)
All India Institute of Medical Sciences Bhopal (IN)
Openalex Percentile: Top 77%
Sarcoma Diagnosis and Treatment
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