Loss of Tripartite Motif–Containing Protein 21 and <scp>UVB</scp> ‐Induced Systemic Inflammation by Regulating <scp>DNA</scp> ‐Sensing Pathways
Taken together, our results indicate that TRIM21 protects against IFN induction at both local and systemic levels by restricting STING signaling.
Authors
- Lihong Huo (ORCID: https://orcid.org/0000-0001-7901-6758)
- Caroline A. Jefferies (ORCID: https://orcid.org/0000-0002-8879-6722)
- Christian Stehlik (ORCID: https://orcid.org/0000-0002-3782-2484)
- Richard I. Ainsworth (ORCID: https://orcid.org/0000-0002-3350-5692)
- Jessica Carrière (ORCID: https://orcid.org/0000-0003-1267-2122)
- Gabriela De Los Santos
- Graziela Perri (ORCID: https://orcid.org/0000-0002-4937-210X)
- Rachel Abuav
- Trinitee Oliver (ORCID: https://orcid.org/0000-0002-2247-8940)
- Gantsetseg Tumurkhuu (ORCID: https://orcid.org/0000-0001-8966-7183)
- Daniel J. Wallace (ORCID: https://orcid.org/0000-0002-2502-1372)
- Arati Naveen Kumar (ORCID: https://orcid.org/0000-0002-9877-5239)
- Lindsy Forbess
- David R. Gibb (ORCID: https://orcid.org/0000-0001-5863-3239)
- Wonwoo Shon (ORCID: https://orcid.org/0000-0002-4852-4896)
- Jeong Min Yu (ORCID: https://orcid.org/0000-0002-9197-1878)
- Richard E. Moore (ORCID: https://orcid.org/0000-0002-5328-9018)
- Mariko Ishimori
Institutions
- Cedars-Sinai Medical Center (US)
- University of California, Los Angeles (US)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2025-06-17
- DOI
- https://doi.org/10.1002/art.43273
- Citations
- 6
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 4.78
Funders
- Cedars-Sinai Medical Center
- National Heart, Lung, and Blood Institute