Design and immunogenic evaluation of multi-epitope vaccines for colorectal cancer: insights from molecular dynamics and In-Vitro studies
This study identified CTL-specific epitopes from DKKL1, FBXO39, and OIP5 as potential targets for colorectal cancer immunotherapy. The multi-epitope vaccine constructs exhibited significant immunogenic potential, providing a foundation for future clinical validation. These findings underscore the promise of these TAAs as key targets for CTL-based vaccine development in colorectal cancer.
Authors
- Zhenglei Xu (ORCID: https://orcid.org/0000-0002-5413-7390)
- Luolin Wang
- Peiwei Sun (ORCID: https://orcid.org/0000-0003-1083-4343)
- Zhong Liu (ORCID: https://orcid.org/0000-0003-1318-2969)
Institutions
- Jinan University (CN)
- Southern University of Science and Technology (CN)
- Southern Medical University Shenzhen Hospital (CN)
- Shenzhen Second People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-06-17
- DOI
- https://doi.org/10.3389/fonc.2025.1592072
- Citations
- 2
- Primary Topic
- vaccines and immunoinformatics approaches
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Shenzhen University