The clinical features, muscle pathology, and role of autophagy in anti-Ku-positive patients
The muscular features were heterogeneous in anti-Ku-positive patients. A predominant myositis pattern was characterized by necrotizing fibers and vacuolar changes in muscle histology, which differ from sIBM and IMNM. Autophagy appeared to be a key mechanism implicated in the pathogenesis.
Authors
- Lingya Qiao
- Ying Lin (ORCID: https://orcid.org/0000-0002-5923-3306)
- Lian Li (ORCID: https://orcid.org/0000-0003-4700-1134)
- Juan Chen (ORCID: https://orcid.org/0009-0008-0675-9591)
- Jiaqi Liu (ORCID: https://orcid.org/0009-0004-9262-3754)
- Mengyang Liu (ORCID: https://orcid.org/0000-0002-1985-3500)
- Qiang Shi (ORCID: https://orcid.org/0000-0002-4694-4272)
Institutions
- Chinese PLA General Hospital (CN)
- Tianjin Huanhu Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-06-17
- DOI
- https://doi.org/10.3389/fimmu.2025.1608735
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- China Health Promotion Foundation