Distribution and metabolism of iPSC-MSCs in the joint cavity of an osteoarthritis rat model
This study was the first to explore the metabolism and distribution of iPSC-MSCs after intra-articular injection by labeling the Antares2 luciferase gene, which provides assurance and theoretical basis for the safety of clinical application of iPSC-MSCs in treating osteoarthritis.
Authors
- Tingpeng Du (ORCID: https://orcid.org/0000-0003-3390-3030)
- Shangxue Yan
- Peng He (ORCID: https://orcid.org/0000-0003-2280-7596)
- Yan Chang (ORCID: https://orcid.org/0000-0001-6684-5960)
- Wei Wei (ORCID: https://orcid.org/0000-0002-2234-4459)
- Feng Zhang (ORCID: https://orcid.org/0000-0001-6994-629X)
- Hongyan Xu (ORCID: https://orcid.org/0000-0002-4916-2567)
- Xulei Wang
- Xiaoyang Yuan
- Gang Cheng
- Peiyao Yang
- Kang Wang (ORCID: https://orcid.org/0000-0003-2603-0956)
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Anhui Medical University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Frontiers in Bioengineering and Biotechnology
- Published
- 2025-06-17
- DOI
- https://doi.org/10.3389/fbioe.2025.1555983
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Anhui Medical University
- Natural Science Foundation of Anhui Province