Tricin selectively combats KRAS-mutant non-small cell lung cancer by inhibiting the PDGF-BB-induced SRC/MAPK/AP-1/PD-L1 signaling pathway and potentiating the antitumor effect of an anti-PD-1 antibody
We believe that tricin is a safe and promising agent for the treatment of patients with KRAS-mutated NSCLC. Our study provides an experimental basis for improving the clinical application of traditional Chinese medicine.
Authors
- Li-Qi Li
- Tao Bao (ORCID: https://orcid.org/0000-0002-0909-6112)
- Xinbing Sui (ORCID: https://orcid.org/0000-0001-7330-0467)
- Huirong Zhu
- Xianmei Zhou (ORCID: https://orcid.org/0000-0001-7662-2306)
- Shiyu Tan
- Lin Zhao
- Xiao‐Sheng Lin (ORCID: https://orcid.org/0000-0002-0944-0075)
- Xiaoman Yang (ORCID: https://orcid.org/0000-0002-8071-7954)
- Hailang He (ORCID: https://orcid.org/0000-0002-7798-500X)
- Bowen Wu (ORCID: https://orcid.org/0000-0002-9822-5528)
- Lin Ye (ORCID: https://orcid.org/0000-0001-6877-3016)
- Jiaxin Li (ORCID: https://orcid.org/0000-0001-6153-7643)
- Hao Zhang (ORCID: https://orcid.org/0000-0002-2058-7123)
- Ying Xie (ORCID: https://orcid.org/0000-0003-3223-1797)
- Zheng Yu-hong
- Yanyu Zhang (ORCID: https://orcid.org/0000-0001-8992-1719)
- Yizhong Zhang (ORCID: https://orcid.org/0000-0003-3035-3037)
- Peiyu Yan (ORCID: https://orcid.org/0000-0002-9372-4803)
- Huihui Chen (ORCID: https://orcid.org/0000-0003-1040-4351)
- Xin Lin (ORCID: https://orcid.org/0000-0002-0594-6319)
- Runze Li (ORCID: https://orcid.org/0009-0005-8759-1783)
Institutions
- Macau University of Science and Technology (MO)
- Guangzhou University of Chinese Medicine (CN)
- Nanjing University of Chinese Medicine (CN)
- Henan University of Traditional Chinese Medicine (CN)
- Hangzhou Normal University (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Guangdong Provincial Hospital of Traditional Chinese Medicine (CN)
- Shenzhen Bao'an District People's Hospital (CN)
- Shuguang Hospital (CN)
- Zhuhai Institute of Advanced Technology (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-06-17
- DOI
- https://doi.org/10.3389/fphar.2025.1594213
- Primary Topic
- Toxin Mechanisms and Immunotoxins
- Type
- article
- Field-Weighted Citation Impact
- 0.00