Tricin selectively combats KRAS-mutant non-small cell lung cancer by inhibiting the PDGF-BB-induced SRC/MAPK/AP-1/PD-L1 signaling pathway and potentiating the antitumor effect of an anti-PD-1 antibody

We believe that tricin is a safe and promising agent for the treatment of patients with KRAS-mutated NSCLC. Our study provides an experimental basis for improving the clinical application of traditional Chinese medicine.

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Publication Details

Journal
Frontiers in Pharmacology
Published
2025-06-17
DOI
https://doi.org/10.3389/fphar.2025.1594213
Primary Topic
Toxin Mechanisms and Immunotoxins
Type
article
Field-Weighted Citation Impact
0.00
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article

Tricin selectively combats KRAS-mutant non-small cell lung cancer by inhibiting the PDGF-BB-induced SRC/MAPK/AP-1/PD-L1 signaling pathway and potentiating the antitumor effect of an anti-PD-1 antibody

Li-Qi Li, Tao Bao, Xinbing Sui, Huirong Zhu et al.
Frontiers in Pharmacology
Toxin Mechanisms and Immunotoxins
article

Tricin selectively combats KRAS-mutant non-small cell lung cancer by inhibiting the PDGF-BB-induced SRC/MAPK/AP-1/PD-L1 signaling pathway and potentiating the antitumor effect of an anti-PD-1 antibody

Li-Qi Li, Tao Bao, Xinbing Sui, Huirong Zhu, Xianmei Zhou, Shiyu Tan, Lin Zhao, Xiao‐Sheng Lin, Xiaoman Yang, Hailang He, Bowen Wu, Lin Ye, Jiaxin Li, Hao Zhang, Ying Xie, Zheng Yu-hong, Yanyu Zhang, Yizhong Zhang, Peiyu Yan, Huihui Chen, Xin Lin, Runze Li
article en

Abstract

We believe that tricin is a safe and promising agent for the treatment of patients with KRAS-mutated NSCLC. Our study provides an experimental basis for improving the clinical application of traditional Chinese medicine.

Frontiers in PharmacologyVol. 16
Macau University of Science and Technology (MO), Guangzhou University of Chinese Medicine (CN), Nanjing University of Chinese Medicine (CN), Henan University of Traditional Chinese Medicine (CN), Hangzhou Normal University (CN), Shanghai University of Traditional Chinese Medicine (CN), Guangdong Provincial Hospital of Traditional Chinese Medicine (CN), Shenzhen Bao'an District People's Hospital (CN), Shuguang Hospital (CN), Zhuhai Institute of Advanced Technology (CN)
Openalex Percentile: Top 85%
Toxin Mechanisms and Immunotoxins
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