Brain microvascular calcification is increased in human donors with dementia compared to elderly controls: a pilot study
Our findings indicate that microvascular calcification impacts brain regions relevant to morphologic changes (hippocampus) and hypoperfusion (posterior cingulate cortex) in AD. Our study expands on a recent report of increased brain calcification in the setting of AD, suggesting that microvascular calcification carries pathophysiological significance in the development and/or progression of AD and related dementias.
Authors
- Daniel Moussouros
- Joseph Aabye
- Isabelle Lombardi
- Kelly Borges (ORCID: https://orcid.org/0000-0002-2989-1367)
- Isabella Romano (ORCID: https://orcid.org/0000-0002-9322-4331)
- Saud Nasruddin
- Mugdha Padalkar (ORCID: https://orcid.org/0000-0003-2043-0801)
- Mackenzie Sivilli
- Olga V. Savinova (ORCID: https://orcid.org/0000-0002-7253-7988)
Institutions
- New York Institute of Technology (US)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2025-06-17
- DOI
- https://doi.org/10.3389/fnagi.2025.1557625
- Citations
- 2
- Primary Topic
- Acute Ischemic Stroke Management
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- New York Institute of Technology
- National Institutes of Health
- National Heart, Lung, and Blood Institute