Young adult cannabis use and circulating endocannabinoid concentrations on cognitive performance
Distinct patterns emerged between 2-AG and AEA concentrations and memory performance among individuals with heavy cannabis. Higher 2-AG concentrations and lower AEA concentrations correlated with improved memory performance in the heavy cannabis use group, suggesting that circulating eCB profiles may serve as a biomarker for cannabis-related cognitive deficits. More work is needed to disentangle the complex relationships between circulating eCB concentrations, cannabis use, and neurocognitive functioning.
Authors
- Margie Hernandez Mejia
- Gianna Andrade (ORCID: https://orcid.org/0000-0003-1273-2877)
- Kelly E. Courtney (ORCID: https://orcid.org/0000-0002-9280-2435)
- Rachel Baca
- Joanna Jacobus (ORCID: https://orcid.org/0000-0002-8587-3673)
- Natasha E. Wade (ORCID: https://orcid.org/0000-0002-9629-2305)
- Cecilia J. Hillard (ORCID: https://orcid.org/0000-0002-9678-748X)
- Alexander L. Wallace (ORCID: https://orcid.org/0000-0002-2224-196X)
- Joseph P. Happer (ORCID: https://orcid.org/0000-0003-2725-8311)
Institutions
- Medical College of Wisconsin (US)
- University of California San Diego (US)
Publication Details
- Journal
- Frontiers in Adolescent Medicine
- Published
- 2025-06-17
- DOI
- https://doi.org/10.3389/fradm.2025.1538448
- Primary Topic
- Cannabis and Cannabinoid Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute on Alcohol Abuse and Alcoholism
- National Institute on Drug Abuse