Interferons and Toxoplasma gondii shape PD-L1 regulation in retinal barrier cells: the critical role of proteases
The parasite <i>T. gondii</i> orchestrates the IFN type I and III dependent retinal immune interaction and downregulates PD-L1 in the oBRB by a protease-dependent mechanism, potentially contributing to immune evasion and inflammation in retinal infection. Our results can pave the way to fully elucidate retinal immune networks and PD-L1 regulation mechanisms, offering potential targets for therapeutic interventions in OT and other retinal inflammatory diseases.
Authors
- Lydia Arnoux
- Benjamin Geiller (ORCID: https://orcid.org/0000-0002-4708-2782)
- Cintia Cevallos (ORCID: https://orcid.org/0000-0002-9268-0853)
- Marie‐Paule Felder‐Schmittbuhl (ORCID: https://orcid.org/0000-0003-3539-1243)
- Alexander W. Pfaff (ORCID: https://orcid.org/0000-0003-3482-1803)
- Iuliia Tsybenko
Institutions
- Institut des Neurosciences Cellulaires et Intégratives (FR)
- Hôpitaux Universitaires de Strasbourg (FR)
- Université de Strasbourg (FR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-06-17
- DOI
- https://doi.org/10.3389/fimmu.2025.1607247
- Citations
- 1
- Primary Topic
- Toxoplasma gondii Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.05
Funders
- Fondation de France