Exploring the differential functions of circulating follicular helper T and peripheral helper T cells in rheumatoid arthritis based on metabolism patterns
Our study suggests that in RA patients, cTfh cells display a more robust B helper-associated function, potentially linked to the CXCL13-CXCR5 axis enhancing glycolysis. Tph cells, on the other hand, show greater cytotoxic activity, possibly due to the CCL2-CCR2 axis increasing mtROS production. Targeting glycolysis or mtROS may offer a novel therapeutic strategy for RA patients.
Authors
- Ziran Bai
- Xia Li (ORCID: https://orcid.org/0000-0001-8018-2358)
- Jingjing Qi (ORCID: https://orcid.org/0000-0002-5224-4416)
- Guan Wang (ORCID: https://orcid.org/0000-0001-5719-5417)
- Cheng Zhang (ORCID: https://orcid.org/0000-0001-8932-0585)
- Siwen Yang
- Huina Huang
- Xianmei Chen (ORCID: https://orcid.org/0000-0003-0457-7563)
- Yawei Tang (ORCID: https://orcid.org/0000-0002-7097-9731)
- Jinyi Ren
Institutions
- Dalian Medical University (CN)
- Second Affiliated Hospital of Dalian Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-06-17
- DOI
- https://doi.org/10.3389/fimmu.2025.1608675
- Citations
- 4
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 3.19
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation