Development of patient-specific iPSC-based epilepsy models and identification of differentially expressed genes for disease mechanisms
The successful establishment of <i>CLCNKB</i>-mutant patient-specific iPSC lines and their transcriptomic characterization provide a valuable tool for studying the molecular basis of epilepsy. These findings underscore the potential of iPSC-based models to advance our understanding of disease mechanisms and support the development of novel diagnostic and therapeutic strategies. Moreover, this study demonstrates the applicability of iPSCs for epilepsy research and their promise in the field of personalized medicine.
Authors
- Yinghong Yang
- Xiaofang Sun (ORCID: https://orcid.org/0009-0000-3822-274X)
- Shunhan Zhang
- Lihao Chen (ORCID: https://orcid.org/0000-0003-1651-8560)
- Jiajia Xian (ORCID: https://orcid.org/0000-0001-9562-987X)
- Shuicheng Yan (ORCID: https://orcid.org/0000-0001-8906-3777)
- Yingjun Xie
- Siqi Huang (ORCID: https://orcid.org/0000-0002-4813-5073)
- Xiaoyan Ma (ORCID: https://orcid.org/0000-0003-1943-9809)
- Jianfeng Wu (ORCID: https://orcid.org/0000-0001-9098-2500)
- Shaoying Li (ORCID: https://orcid.org/0000-0003-0064-0633)
- Furong Ma
Institutions
- Third Affiliated Hospital of Guangzhou Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Neuroscience
- Published
- 2025-06-17
- DOI
- https://doi.org/10.3389/fnins.2025.1582255
- Citations
- 1
- Primary Topic
- Genetics and Neurodevelopmental Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.82