Identification of anoikis-related subtypes and a risk score prognosis model, the association with TME landscapes and therapeutic responses in hepatocellular carcinoma
Our findings reveal that anoikis-related molecular classification is closely linked to HCC prognosis and immune landscape. The established prognostic model has potential clinical utility for risk stratification and treatment guidance. TTC26 may serve as a novel biomarker and therapeutic target in HCC.
Authors
- Hao Zhang (ORCID: https://orcid.org/0000-0003-4080-3222)
- Xiangyu Zhai
- Bin Jin (ORCID: https://orcid.org/0000-0002-1411-2631)
- Xinlu Zhang (ORCID: https://orcid.org/0000-0001-7668-091X)
- Hailing Ding
- Chongzhong Liu
- Kecheng Li (ORCID: https://orcid.org/0000-0001-8862-9943)
- Zili Zhang
- Huaxin Zhou
- Yanmei Wu
Institutions
- Qilu University of Technology (CN)
- Fourth People’s Hospital of Jinan (CN)
- Second Hospital of Shandong University (CN)
- Jinan Central Hospital (CN)
- Center for High Pressure Science & Technology Advanced Research (CN)
- Shandong Maternal and Child Health Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-06-17
- DOI
- https://doi.org/10.3389/fimmu.2025.1602831
- Citations
- 1
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Natural Science Foundation of Shandong Province
- National Key Research and Development Program of China