In Silico Study of Natural Alkaloids as Rage Inhibitor for the Treatment of Meningitis

Meningitis is a critical condition of CNS, which may include long-term neurological complications, such as hearing impairment or focal neurological deficits.Receptor for advanced glycation end products (RAGE) regulates metabolism, inflammation and survival of epithelium in stress determination.As mentioned in literature, natural alkaloids have great significance as RAGE inhibitors.Molecular docking study was performed on a series of 25 natural alkaloids showing anti-inflammatory, antioxidants, and neuro-protective action in the brain.The docking technique was used to dock a set of representative compounds within a target site of 6XQ3 using PyRx virtual screening software.Molecular docking has become a significant parameter of in-silico drug development in current conditions, which involves interactions between ligands and proteins at atomic levels.Molecular docking aims to analyze the ligands proteins complex through computational techniques.