Antibiotic-Peptide Conjugates as Potential Quorum Sensing Inhibitors in Biofilm-Producing MDR Pathogens: An Updated Review

Bacteria have various strains some can be beneficial and some are pathogenic.The pathogenic strains of bacteria are dangerous as they have caused several critical and untreatable diseases and till now their pathogenesis is ever increasing.Those diseases are becoming incurable because of the increment of the resistant mechanism of bacteria.Traditional antibiotics are not effective against pathogenic strains of bacteria like MRSA, E.coli, Streptococcus pneumonia; Klebsiella sp.due to the evolution of drug resistance mechanisms, etc.A new strategy has been introduced which is combinatorial therapy.In this combinatorial therapy, antimicrobial peptides (AMP) and antibiotics are combined and applied against drug-resistant bacteria.Much research reveals that combinatorial therapy shows more efficacy against the pathogenic strain than the antibiotic or AMP alone.This review focuses specifically on the structure of AMP, how it works, and helps antibiotics to enhance their actions specifically as combinatorial therapy and its therapeutic output.