Cell-free DNA profiles of dermatomyositis and its potential role in discriminating phenotypes
This study presents the first comprehensive depiction of cfDNA profiles in patients with dermatomyositis. Furthermore, cfDNA features exhibit variability across some sub-phenotypes and may serve as discriminatory indices. Finally, potential involvement of extracellular DNases in cfDNA profiles in dermatomyositis shall be further investigated.
Authors
- Heng Zhang (ORCID: https://orcid.org/0000-0001-8243-1469)
- Ru Dai (ORCID: https://orcid.org/0000-0002-2691-8544)
- Zhuangli Tang (ORCID: https://orcid.org/0000-0001-8390-079X)
- Meijie Zhang (ORCID: https://orcid.org/0000-0001-8463-5393)
- Hua-Li Cao (ORCID: https://orcid.org/0000-0001-8328-3891)
- Xiao‐Yong Man (ORCID: https://orcid.org/0000-0003-3331-5538)
- Pengyu Chen (ORCID: https://orcid.org/0000-0003-3380-872X)
- Yaqi Wang (ORCID: https://orcid.org/0000-0002-7261-4947)
- Xueyan Chen (ORCID: https://orcid.org/0000-0002-3073-7180)
- Yuan Zhou (ORCID: https://orcid.org/0009-0007-8184-2005)
- Yuequn Lou (ORCID: https://orcid.org/0000-0001-6984-8876)
- Yanhong Sun
Institutions
- Second Affiliated Hospital of Zhejiang University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-06-17
- DOI
- https://doi.org/10.3389/fimmu.2025.1605121
- Primary Topic
- Inflammatory Myopathies and Dermatomyositis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China