Identifying potential three key targets gene for septic shock in children using bioinformatics and machine learning methods
In this study, three core genes (CD163, MCEMP1 and RETN) that lead to sepsis death in children were screened out, providing a new understanding of the lethal mechanism of sepsis in children and a promising new therapeutic approach.
Authors
- Wei Guo (ORCID: https://orcid.org/0000-0001-5586-2407)
- Kezhu Chen (ORCID: https://orcid.org/0000-0001-9710-708X)
- Feng Wang
- Hao Chen (ORCID: https://orcid.org/0000-0002-2680-6921)
- Shan Wang (ORCID: https://orcid.org/0000-0003-4582-0371)
- Chen Hong (ORCID: https://orcid.org/0000-0003-1244-3506)
- Wei Zhang (ORCID: https://orcid.org/0000-0001-8588-2409)
- Yifan Chi (ORCID: https://orcid.org/0000-0001-9878-4736)
Institutions
- Harbin Medical University (CN)
- Heilongjiang University of Chinese Medicine (CN)
- Heilongjiang Academy of Sciences (CN)
- First Affiliated Hospital of Heilongjiang University of Chinese Medicine (CN)
- Shaanxi Provincial Hospital of Traditional Chinese Medicine (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-06-17
- DOI
- https://doi.org/10.3389/fimmu.2025.1586584
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00