Trisodium Citrate Driven Hydrotropic Analysis: A Novel Approach for Ibuprofen Determination

The term "hydrotropy" refers to the enhancement of the solubility of a drug or various substances.Various organic solvents are commonly used to enhance the solubility of drugs, but these solvents can be hazardous in nature.To replace organic solvents, various hydrotropic agents, such as Trisodium citrate, sodium benzoate, urea, Nicotinamide, sodium salicylate, sodium glycinate, and sodium Ascorbate, have been observed to increase the solubility of many poorly water-soluble drugs.The present work focuses on the application of hydrotropy, specifically the enhancement of the solubility of the drug ibuprofen in 1.25 M Trisodium citrate (a hydrotropic agent).This study demonstrates the enhancement of the solubility of the practically water-insoluble drug ibuprofen, allowing for titrimetric assay analysis without the use of organic solvents.