Gastroprotective Effects of S-Adenosyl-L-Methionine Through Its Antioxidant and Anti-inflammatory Properties on Dextran Sulfate Sodium-Induced Chronic Colitis in Swiss Albino Mice

According to our study's findings, SAMe exerts a gastroprotective effect comparable to that of sulfasalazine, as evidenced by the reduction in DAI, colon weight-by-length ratio, macroscopy grading, histopathology score, and TNF-α level. The increase in the GSH levels by SAMe signifies a decrease in oxidative stress, which may be responsible for the gastroprotective effect.