Urolithin A attenuates pulmonary fibrosis via the PI3K/AKT/mTOR pathway: Evidence from network pharmacology and experimental validation

UA exerts therapeutic effects on PF by targeting the PI3K/AKT/mTOR pathway, particularly through the inhibition of AKT1 phosphorylation. These findings indicate that UA has potential as a therapeutic candidate for PF and provide a novel perspective for utilizing gut microbiota metabolites in the treatment of fibrotic diseases. Further studies are needed to elucidate the precise mechanisms of UA.

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Publication Details

Journal
Biochemical and Biophysical Research Communications
Published
2025-06-17
DOI
https://doi.org/10.1016/j.bbrc.2025.152219
Citations
1
Primary Topic
Pomegranate: compositions and health benefits
Type
article
Field-Weighted Citation Impact
1.12
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article

Urolithin A attenuates pulmonary fibrosis via the PI3K/AKT/mTOR pathway: Evidence from network pharmacology and experimental validation

Wei Wang, Kai Gao, Zhaoxing Dong, Jiangpo Ma
1 citations
Biochemical and Biophysical Research Communications
Pomegranate: compositions and health benefits
1.12
article

Urolithin A attenuates pulmonary fibrosis via the PI3K/AKT/mTOR pathway: Evidence from network pharmacology and experimental validation

Wei Wang, Kai Gao, Zhaoxing Dong, Jiangpo Ma
article en
1 citations

Abstract

UA exerts therapeutic effects on PF by targeting the PI3K/AKT/mTOR pathway, particularly through the inhibition of AKT1 phosphorylation. These findings indicate that UA has potential as a therapeutic candidate for PF and provide a novel perspective for utilizing gut microbiota metabolites in the treatment of fibrotic diseases. Further studies are needed to elucidate the precise mechanisms of UA.

Biochemical and Biophysical Research CommunicationsVol. 776
Ningbo No. 2 Hospital (CN), Ningbo No.6 Hospital (CN)
Zero hunger
Openalex Percentile: Top 23%
Pomegranate: compositions and health benefits
1.12
DOIOpen Access PDFOpenAlex
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Urolithin A attenuates pulmonary fibrosis via the PI3K/AKT/mTOR pathway: Evidence from network pharmacology and experimental validation — Wei Wang, Kai Gao, et al. · Biochemical and Biophysical Research Communications (2025) | TGRS Research Map | TGRS