Liraglutide improves depressive and cognitive deficits in a high-fat diet rat model of obesity: the role of hippocampal autophagy and the PI3K/Akt/mTOR pathway
This work highlights the antidepressant and pro-cognitive properties of liraglutide in HFD-exposed rats, which could be mediated through amelioration of the disrupted PI3K/Akt/mTOR signaling activity with a possible impedance of the exaggerated autophagy-mediated neurodegenerative cascades. Indeed, this study highlights that liraglutide is not only effective in weight control, but its effects also extend to managing obesity-related psychiatric disorders.
Authors
- Mohamed Z. Habib (ORCID: https://orcid.org/0000-0001-7161-8121)
- Mohammed R. Rabei (ORCID: https://orcid.org/0000-0001-9685-7399)
- Sara Khedr
- Hagar Yousry Rady (ORCID: https://orcid.org/0000-0003-1980-4431)
- Yosra Magdy (ORCID: https://orcid.org/0000-0002-1226-3057)
- Sherif A. Kamar (ORCID: https://orcid.org/0000-0002-3682-869X)
Institutions
- Al-Ahliyya Amman University (JO)
- Ain Shams University (EG)
- Sinai University (EG)
- Mansoura University (EG)
- Armed Forces College of Medicine (EG)
Publication Details
- Journal
- Psychopharmacology
- Published
- 2025-06-17
- DOI
- https://doi.org/10.1007/s00213-025-06834-7
- Citations
- 6
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 3.47
Funders
- Ain Shams University
- Science and Technology Development Fund