A case report of bladder cancer-related acquired hemophilia A

Acquired hemophilia A is an extremely rare (incidence of 1.5/1,000,000) and potentially life-threatening disorder characterized by the production of autoantibodies against coagulation factor VIII with a consequent increased bleeding risk; it mainly affects elderly people, and approximately 6-22% of the cases are cancer-related. We report the case of an 84-year-old man who presented with subcutaneous hematomas and anemia; he had prolonged activated partial thromboplastin time, coagulation factor VIII deficiency, and high levels of factor VIII antibodies, and he was successfully treated with prednisone, cyclophosphamide, and recombinant activated factor VII as a bypassing agent.