ASSESSMENT OF SERUM CTRP12 AND ADIPSIN AS POTENTIAL BIOMARKERS FOR CHRONIC KIDNEY DISEASE IN THE IRAQI POPULATION

Objective: The blood levels of Cystatin C and creatinine, as well as glomerular filtration rate (GFR), in clinical practice to assess impaired kidney function, particularly the existence of albuminuria. Although they are often employed, estimates of GFR mentioned above are not exact. As a result, early-stage chronic kidney disease (CKD) may continue to be undiagnosed. It is crucial to emphasize that early CKD treatment can either improve kidney function or, at the very least, halt the disease’s progression. In our study, we wish to find at the levels of serum Adipsin and C1q/ Tumor Necrosis Factor -related protein-12 (CTRP12) among the CKD subjects from the Iraqi population Methods: We estimated serum Adipsin and CTRP12 levels using the ElabScience Enzyme-Linked Immunosorbent Assay kits. Along with these protein levels, we tried to find the possible correlation between several blood markers and chronic renal disease in the subjects. Results: When compared to controls, the individuals’ serum creatinine, blood urea, uric acid in serum, and CRP levels were discovered to be greater (p<0.01). The glomerular filtration rate and it was discovered that the sufferers’ group had lower calcium levels than the group with control (p<0.01). CTRP12 was discovered to be reduced, whereas it was discovered that Adipsin was higher than the control (p<0.01). From multiple correlation studies, we found that Adipsin and CTRP12 presented a positive relation (r=0.164129), and CRP with CTRP12 showed a positive relation (r=0.160291). Conclusion: From this, we can conclude that serum levels of CTRP12 and Adipsin should be used as novel markers to detect CKD in both early and disease progression stages.