Cimifugin improves neuronal function in rat with focal cerebral ischemic injury by inhibiting oxidative stress, neuronal apoptosis and iNOS/COX-2 signaling pathway

Cimifugin confers neuroprotection in cerebral I/R injury through multi-targeted mechanisms involving antioxidant, anti-inflammatory, and anti-apoptotic actions. These findings suggest its potential as a low-toxicity, plant-derived candidate for managing ischemic stroke and related cerebrovascular diseases.