Prevalence of Restless Leg Syndrome and Its Association With Iron Deficiency in Patients With Chronic Kidney Disease: A Cross-Sectional Observational Study

RLS is highly prevalent among CKD patients, especially those on dialysis, and shows a strong association with iron deficiency. Reduced serum ferritin, TSAT, and serum iron levels indicate that impaired iron metabolism contributes significantly to RLS in this population. Functional iron deficiency, even with normal ferritin, may underlie persistent symptoms. Early recognition and targeted iron therapy could reduce RLS burden and improve sleep, mood, and quality of life in CKD patients. Further multicenter studies are needed to validate these findings and develop standardized management protocols.