A Study of the Inclusion Complex Formed Between Cucurbit[8]uril and N,4-Di(pyridinyl)benzamide Derivative
The interaction between cucurbit[8]uril (Q[8]) and the guest 1-methyl-4-(4-(1-methylpyridin-1-ium-4-yl)benzamido)pyridin-1-ium (PB2+) has been thoroughly investigated. Multiple techniques were employed, including 1H NMR spectroscopy, mass spectrometry, isothermal titration calorimetry (ITC), UV–vis absorption spectrophotometry, and quantum chemistry calculations. The experimental results and calculation analysis have clearly shown that in aqueous solution, the host Q[8] preferentially encapsulates the phenylpyridinium salt moiety of the PB2+ guest within its hydrophobic cavity, forming a 1:2 inclusion complex.
Authors
- Gang Wei (ORCID: https://orcid.org/0000-0001-6261-2115)
- Zhong‐Zheng Gao (ORCID: https://orcid.org/0000-0002-9162-709X)
- Weibo Yang (ORCID: https://orcid.org/0000-0003-1633-7655)
- Hui Zhao (ORCID: https://orcid.org/0000-0001-8585-8222)
- Jifu Sun (ORCID: https://orcid.org/0000-0001-7536-9759)
- Zhikang Wang (ORCID: https://orcid.org/0000-0001-9587-1965)
- Mingjie Yang (ORCID: https://orcid.org/0009-0008-7907-2627)
Institutions
- Commonwealth Scientific and Industrial Research Organisation (AU)
- Minzu University of China (CN)
- Mineral Resources (AU)
- Shandong University of Science and Technology (CN)
Publication Details
- Journal
- Organics
- Published
- 2025-06-17
- DOI
- https://doi.org/10.3390/org6020026
- Citations
- 1
- Primary Topic
- Supramolecular Chemistry and Complexes
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Hainan Normal University
- Natural Science Foundation of Shandong Province