Synthesizes Azo derivatives linked 1,2,3-triazols ring and studying their biological activity

In this research we studied the synthesis of Azo derivatives which linked 1,2,3-triazols ring and studying the biological activity of this derivatives. We use a primary amine which is N,N-diaminodiphenylmethan as an initiator for the reaction this amine reacted with NaNO2 \HCl than with 1-methyl-1H-1,2,3-triazole-4-carbaldehyde in presence NaOH to produce compound (1) , after that the (1) compound reacted with p-aminoacetophenone using ethanol as solvent and NaOH as catalyst to give chalcone (2), which is reacted with urea, phenyl hydrazine, hydrazine hydrate to produce thiazine derivative (3), pyrazole derivative (4) and pyrimidine derivative (5) respectfully. Compounds characterization was achieved by FT-IR,13C-NMR and 1H-NMR then we studied their biological activity which was founded that all prepared Compounds have good activity

Publication Details

Journal
Muthanna Journal of Pure Science
Published
2025-06-17
DOI
https://doi.org/10.52113/2/12.01.2025/104-116
Primary Topic
Synthesis and Characterization of Heterocyclic Compounds
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Synthesizes Azo derivatives linked 1,2,3-triazols ring and studying their biological activity

Muthanna Journal of Pure Science
Synthesis and Characterization of Heterocyclic Compounds
article

Synthesizes Azo derivatives linked 1,2,3-triazols ring and studying their biological activity

article en

Abstract

In this research we studied the synthesis of Azo derivatives which linked 1,2,3-triazols ring and studying the biological activity of this derivatives. We use a primary amine which is N,N-diaminodiphenylmethan as an initiator for the reaction this amine reacted with NaNO2 \HCl than with 1-methyl-1H-1,2,3-triazole-4-carbaldehyde in presence NaOH to produce compound (1) , after that the (1) compound reacted with p-aminoacetophenone using ethanol as solvent and NaOH as catalyst to give chalcone (2), which is reacted with urea, phenyl hydrazine, hydrazine hydrate to produce thiazine derivative (3), pyrazole derivative (4) and pyrimidine derivative (5) respectfully. Compounds characterization was achieved by FT-IR,13C-NMR and 1H-NMR then we studied their biological activity which was founded that all prepared Compounds have good activity

Muthanna Journal of Pure ScienceVol. 12(1)
Openalex Percentile: Top 89%
Synthesis and Characterization of Heterocyclic Compounds
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.