Naringenin attenuates slow-transit constipation by regulating the AMPK/mTOR/ULK1 signalling pathway: in vivo and in vitro studies
NAR attenuates the AMPK/mTOR/ULK1 pathway in ICCs, thereby improving STC colonic dysmotility and underscoring its promise as a therapeutic option for STC.
Authors
- Shuai Yan (ORCID: https://orcid.org/0000-0003-1053-8018)
- Lianlin Su (ORCID: https://orcid.org/0000-0002-9282-3121)
- Yifei Qian
- Yahui Wang (ORCID: https://orcid.org/0000-0001-6645-8485)
- Xiaopeng Wang (ORCID: https://orcid.org/0000-0002-4747-8197)
- Huiju Yang
- Mingming Sun (ORCID: https://orcid.org/0000-0001-7178-6969)
Institutions
- Nanjing University of Chinese Medicine (CN)
- University of Wisconsin–Madison (US)
- Suzhou Traditional Chinese Medicine Hospital (CN)
- Third Affiliated Hospital of Zhengzhou University (CN)
- First Affiliated Hospital of Henan University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-06-17
- DOI
- https://doi.org/10.3389/fphar.2025.1550458
- Citations
- 2
- Primary Topic
- Gastrointestinal motility and disorders
- Type
- article
- Field-Weighted Citation Impact
- 3.62
Funders
- Jiangsu Commission of Health
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province