The impact of respiratory tract mimicking media on antifungal susceptibility testing
The rise in antifungal resistance and changing epidemiology underscores the need to improve antifungal susceptibility testing. This study tested the standard medium RPMI<sub>1640</sub> and healthy lung and sinus media against <i>Aspergillus</i>, <i>Mucor</i>, and <i>Candida</i> species. <i>Candida</i> showed greater variability in minimum inhibitory concentrations (MICs) compared with molds, with higher MICs in respiratory tract-mimicking media than in RPMI<sub>1640</sub>. <i>Aspergillus terreus</i> was the most affected mold, showing higher MICs for certain antifungals in these media.
Authors
- Roya Vahedi‐Shahandashti (ORCID: https://orcid.org/0000-0001-7518-7795)
- Daniel R. Neill (ORCID: https://orcid.org/0000-0002-7911-8153)
- Joanne L. Fothergill (ORCID: https://orcid.org/0000-0002-7012-1508)
- Cornelia Lass‐Flörl (ORCID: https://orcid.org/0000-0002-2946-7785)
- Hollie Leighton (ORCID: https://orcid.org/0009-0001-2227-2387)
- Isabella Hofer
Institutions
- Innsbruck Medical University (AT)
- University of Liverpool (GB)
- University of Dundee (GB)
- Universität Innsbruck (AT)
Publication Details
- Journal
- Antimicrobial Agents and Chemotherapy
- Published
- 2025-06-17
- DOI
- https://doi.org/10.1128/aac.00225-25
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Austrian Science Fund