Cerebrospinal Fluid Metabolome in Central Nervous System Infections: A Study of Diagnostic Accuracy
CSF metabolites demonstrate high diagnostic accuracy for CNS infections, particularly bacterial meningitis. Combinations further improve the diagnostic performance, exceeding that of CSF leukocytes alone. These findings highlight the potential of cerebrospinal fluid metabolites to improve diagnostic accuracy in clinical practice. ANN NEUROL 2025;98:851-863.
Authors
- Matthijs C. Brouwer (ORCID: https://orcid.org/0000-0001-7775-7843)
- Frédéric M. Vaz (ORCID: https://orcid.org/0000-0002-9048-1041)
- Bauke V. Schomakers (ORCID: https://orcid.org/0000-0002-0242-9113)
- Michel van Weeghel (ORCID: https://orcid.org/0000-0002-4916-2866)
- Sabine E. Olie
- Diederik van de Beek (ORCID: https://orcid.org/0000-0002-4571-044X)
- Steven L. Staal
Institutions
- Emma Kinderziekenhuis (NL)
- Netherlands Metabolomics Centre (NL)
- Amsterdam Neuroscience (NL)
- Amsterdam University Medical Centers (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2025-06-17
- DOI
- https://doi.org/10.1002/ana.27291
- Citations
- 3
- Primary Topic
- Bacterial Infections and Vaccines
- Type
- article
- Field-Weighted Citation Impact
- 3.55
Funders
- ZonMw
- H2020 European Research Council